During this time he can walk over enemies to mark them for death. Unlike the regular D6, rerolled items can pick from any item pool, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Eden, When used, Isaac dies and becomes The Lost for the current room. The more items in a pool, the more likely that pool will be picked, A familiar grey spider that wanders around and allows you to see your tear damage and the health bars of all enemies, The spider will inflict a random status effect on any enemies it comes into contact with (e.g. Dinner = +0.5 tears, +0.2 shot speed. When used, this will combine with your other active item, creating a unique flame and possibly giving special effects, The recharge time of this item is based on your 2nd active item, otherwise it's 4 rooms, While held, guarantees the first Devil/Angel Room encountered to be an Angel Room, and increases the overall chance of getting one, A maximum of 16 flames can be active at one time around Isaac, Counts as 1 of 3 book items needed towards the Bookworm transformation, UNLOCK: Unlock this item by defeating Isaac as Bethany, A single use active item that will spawn 3 soul hearts and 2 items from the Angel Room pool, Starts fully uncharged and gains charges only through picking up soul and black. white, grey, gray, A familiar that follows isaac around dropping white creep which slows down enemies that walk over it, Spawns 1-2 familiar blue spiders after every room, * item room, treasure room, item room pool, white, ball, dripping, A familiar that is controlled via the arrow keys and will automatically fire a laser if anything is in its line of sight, Robo-Baby 2.0's lasers deal 3.5 damage per hit, UNLOCK: Unlock this item by beating Challenge #16 (Computer Savvy), * robo baby 2.0, item room, treasure room, item room pool, red, eyes, grey, gray, robot, A familiar which follows Isaac and spawns a blue flies as you're firing tears, Rotten Baby can only create one fly at a time, meaning if he has created a fly he cannot make another until it is used, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, dead, baby, spikes, creep). It grows rapidly in size then explodes into a gas cloud that damages nearby enemies, When the explosion happens, more homing fungus tears fire out in random directions. *, stone, rock, grey, gray, white, dice, pip, broken, die, While held this trinket causes all pickups and enemies to move slowly towards you, Will also attract the Mom's Foot and Ultra Greed door entities, *, white, grey, gray, pill, medicine, drug, Randomly Isaac will gain a camouflage for a few seconds and all enemies in the current room will have a confused status effect applied to them, This trinket can be used to open the door to Mausoleum in Depths II, Gives a small chance to spawn a friendly attack spider while in a hostile room with enemies, Leaves a pool of green creep under all bombs you place, which damages enemies that walk over it, *, green, bogey, snot, ocarina, bobs bladder, bob bladder, Gives a +6.66% chance of a getting a small battery after clearing a room, Gives a +2.0% chance for pickups to be small batteries, Gives a +5.0% chance to add an extra charge to your active item after clearing a room, *, metal, grey, gray, silver, pill, cross, Exploding bombs now have a chance to drop another bomb that you can pick up, Higher chance to find crawl spaces when exploding rocks, UNLOCK: Unlock this trinket by beating Challenge #27 (Brains), *, toe, finger, thumb, grey, gray, black, red, yellow, Gives a different trinket effect per room, randomly choosing between any of the other available trinkets in the game. 4 keys = 50% chance. Creator Edmund McMillen called it the "best version of Isaac". If used with Brimstone you have a 100% chance to fire a laser out the back of your head, * dungeon room, blood challenge room, arena pool, item room, treasure room, item room pool, He behaves the same as how Esau works with Jacob, following your exact movements, Disappears after the current room or if he takes enough damage and dies, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Forgotten, Creates 6 wisps, similar to the Book of Virtues effect, Mosts wisps will be the standard blue ones, but have a chance to have random special properties, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Bethany, Spawns Esau as a temporary familiar, who copies your exact movements the same as how the Jacob & Esau character works, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Jacob, Once picked up, you gain unlimited key use for the rest of the floor, Using a 'Bombs are Key' pill with this effect will swap your Gold Key for a Gold Bomb, Once picked up, you gain unlimited bomb use for the rest of the floor, Using a 'Bombs are Key' pill with this effect will swap your Gold Bomb for a Gold Key, UNLOCK: Unlock this item by beating challenge #23 (Blue Bomber), Fully charges your active item when picked up, Also, you take a full heart of damage when picked up. When used, this card drops all of your hearts (including non-red hearts), coins, keys and bombs on the floor, This effect is done in the most efficient way possible - e.g. Broken hearts permanently subtract from your total possible health containers, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Magdalene, Isaac turns to stone and can't move for 10 seconds, but your tear rate goes up significantly for the duration, UNLOCK: Unlock this card by defeating challenge #42 (Hot Potato), UNLOCK: Unlock this card by defeating challenge #43 (Cantripped), "May you see the value of all things in life", When used, all items and pickups in the current room are turned into money. The damage formula of the bombs has changed from damage * 5 + 30 to damage * 10, UNLOCK: Unlock this item by beating Mom's Heart 9 times, * item room, treasure room, item room pool, baby, fetus, foetus, jar, white, pink, bug, dr fetus, Causes pickups on the floor move towards the player, Works across pits, but not through Key blocks, REPENTANCE - Magneto is now capable of opening chests from a small distance. Breakfast = +0.2 shot speed, +1.5 Range. Can cause white poops through other item effects such as A Card Against Humanity or Re-Lax pills. However after the attack you end up near the boss, which puts you in danger of taking damage too, Scales in damage and area of effect with the player's size, UNLOCK: Unlock this item by defeating Delirium as Jacob & Esau, When used will do a swipe attack in any direction. This effect also works on Delirium if it is currently transformed into The Haunt while below half health, UNLOCK: Unlock this item by defeating Greedier mode as Bethany, Identified all pills on pickup, and converts them to their worse counterparts (e.g. If you didn't find one before this point, there will be a tinted Skull somewhere on Depths II, which contains a Fool card when blown up. Lazarus - Every time Lazarus dies, gives +21.6 temporary Damage Up, gradually fading over 1 minute. devil room pool, devil deal, paper, pink, brown, isaac, Gives a 50% chance to not take damage from projectiles, * golden chest pool, gold chest pool, secret room pool, item room, treasure room, item room pool, ?, Satan and The Lamb as Tainted Magdalene, The first time you pick this trinket up, the heart container will be filled. * boss room pool, boss room item, mr. squeezy, mr squeezy, cobaltstreak, white, brown, red, bow, * boss room pool, boss room item, purple, carton, grape drank, When picked up, spawns 1 red heart, 1 key, 1 bomb, 1 coin, 1 card/rune, 1 pill and 1 trinket, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, brown, orange, cardboard, Doubles the yield of hearts, coins, bombs and keys that spawn from non-red chests, Item Pool: Shop, Challenge Room, Key Beggar, Mom's Chest, * key master pool, key beggar pool, key judgement pool, , dungeon room, blood challenge room, arena pool, shop room pool, shop item pool, golden, horns, moms key, mom key, Tears have a random chance to charm enemies, Charmed enemies will prioritize attacking other enemies in the room, otherwise they will still attack Isaac, The chance to charm enemies is affected by your luck stat and at +27 Luck it will activate every time, * dungeon room, blood challenge room, arena pool, item room, treasure room, item room pool, UNLOCK: Unlock this item by beating the Boss Rush with Azazel, * devil pool, devil room pool, devil deal, grey, gray, bloody, Spawns a trapdoor at Isaac's feet which allows him to travel to the next floor, Digging in certain spots with objects or markings on the floor will guarantee a crawlspace once per floor, In Sheol, Cathedral, Chest and Dark Room this item either opens a Crawl Space, or does nothing, Cannot spawn a trapdoor directly infront of a secret room entrance, Can destroy rocks if used when Isaac is flying over a rock, * secret room pool, devil pool, devil room pool, devil deal, silver, grey, gray, dig, spade, shovel, * shop room pool, shop item pool, item room, treasure room, item room pool, brown, pink, When used, spawns a Monstro which will jump on a random enemy in the room, dealing 120 damage and destroying nearby obstacles, UNLOCK: Unlock this item by beating the Basement II for the first time, * item room, treasure room, item room pool, white, grey, gray, bloody, monstros tooth, monstro tooth, Everytime you fire a tear, there is a chance that you will also fire three more tears in all cardinal directions, The chance to fire 4-way tears is affected by your luck stat and at +15 Luck it will activate every time, At +0 luck the effect has a 30% chance to activate, UNLOCK: Unlock this item by beating Lokii for the first time, * item room, treasure room, item room pool, grey, gray, devil, lokis horns loki horns, A familiar that follows Isaac and charges forwards, dealing 3.5 damage per tick to any enemies it comes into contact with, REPENTANCE - The damage tick rate on Little Chubby has been increased, UNLOCK: Unlock this item by beating the Caves II for the first time, * item room, treasure room, item room pool, yellow, smile, face, bug, Tears now have a chance of slowing enemies and their projectiles for 2.5 seconds, The chance to slow enemies is affected by your luck stat and at +15 Luck it will activate every time, * item room, treasure room, item room pool, black, grey, gray, red, bug, Has a chance to drop when exploding a tinted rock, UNLOCK: Unlock this item by destroying 100 tinted rocks, * tinted rock, marked rock, grey, gray, lump, white, Reveals adjacent rooms up to 2 rooms away, this includes revealing if you're next to a Secret Room or Super Secret Rooms, Gives Isaac a slight glow when Curse of Darkness is active, Blocks damage from projectiles falling from above, * item room, treasure room, item room pool, spelunky, miner, mining, helpmet, light, purple, olmec yama The recharge time of this item depends on the Rune/Soul Stone held: 2 rooms: Rune of Ansuz, Rune of Berkano, Rune of Hagalaz, Soul of Cain, 3 rooms: Rune of Algiz, Blank Rune, Soul of Magdalene, Soul of Judas, Soul of ?? You need to move out of the way or it will hurt Isaac, but can be used to open anything requiring a bomb e.g. Maggy - +1 HP up. How to Unlock The Lost, The Forgotten, and The Keeper (All Characters) - The Binding of Isaac . Counts as 1 of 3 evil items needed towards the Leviathan transformation. This doesn't work with The Lost characters, While in a room with enemies, red cracks will appear on the floor in random locations, Walking over the crack spawns a white soul familiar, that launches itself into the nearest enemy, exploding and dealing double your tear damage to everything near it, Cracks will keep appearing but only one can exist in the room at a time, UNLOCK: Unlock this item by defeating challenge #38 (Baptism by Fire), While held, this item spawns a familiar that can be moved around using the arrow keys and deals 1.5 damage per tick to any enemies it touches, When activated, you teleport, swapping places with wherever Stitches was positioned, Teleporting next to fires will extinguish them (including blue fires) and on top of shopkeepers will destroy them (gives +10% devil/angel room chance as normal), If used while stitches is on top of an enemy, it can be used to telefrag enemies, dealing x3.5 your damage + 40, Can be used to enter/exit Curse Rooms for free by teleporting infront of the door while holding the direction key to move in immediately. Half hearts heal a whole heart and full hearts heal 2 red hearts, UNLOCK: Unlock this item by beating Boss Rush with Maggy, * item room, treasure room, item room pool, the lost item pool, pink, purple, candy, Each time you enter a new room, damage is negated for the first time you get hit, Can be used to go in and out of a Curse Room without taking damage. The second knife piece is on the second floor of the Mines. Abel, UNLOCK: Unlock this trinket by defeating Isaac, ?? 1. Nicalis, Inc. has announced that The Binding of Isaac: Repentance has been given a huge new update, bringing the DLC in line with the PC version of the game. Can be used to store up to 8 consumables in, such as hearts, coins, keys, bombs, cards etc, When the bag has 8 items you can hold down the activate button for 2 seconds to craft yourself a brand new random item, Bag of Crafting's recipes are based on your current seed, but there are some fixed recipes that exist in every run, e.g. ?, Satan and The Lamb as Tainted Judas, Changes Devil Room layouts. The anticipated final DLC to The Binding Of. Killing a petrified enemy will freeze it. The goal here is to add killer items into the pool in order to improve the average run and make achieving completion marks easier. Stat Up becomes Stat Down), Any 'Stat down' pills you take give you a permanent +0.6 Damage Up (Horse pills +1.2), Most other pills spawn a black heart when used, including R U A Wizard?, Amnesia, Bad Trip, ?? Charge time increased to 4 (from 2), UNLOCK: Unlock this item by dying 100 times, * item room, treasure room, item room pool, grey, gray, Holding the active item button will deplete the charge bar. When you take damage and the cannon breaks, you take an additional 2 full hearts of damage and gain the Anemic effect for the room. Explosions now only heal Isaac for half of a heart (previously healed a full heart), * item room, treasure room, item room pool, fire, heart, orange, burning, stannis, Makes tears break into 4 smaller tears on impact with anything, which deal half of your damage, * item room, treasure room, item room pool, brown, orange, headless, crickets body, When getting hit, this item has a chance to drop a soul heart or black heart, The chance to spawn a heart is affected by your luck stat and at +22 Luck it will activate 50% of the time, Enemies have a chance to drop half a red heart when killed, Item Pool: Item Room, Devil Room, Curse Room, Demon Beggar, * curse room pool, demon beggar pool, demon judgement pool, devil beggar pool devil pool, devil room pool, devil deal, item room, treasure room, item room pool, gimp mask, the lost item pool, grey, gray, black, An item only found in the secret room pool, * secret room pool, , the lost item pool, purple, black, grey, gray, flower, mtg magic the gathering, vintage, When you take damage, 1-2 coins will drop on the floor, When playing as the Keeper, this item drops 0-1 coins instead, * shop room pool, shop item pool, item room, treasure room, item room pool, pink, oink, Isaac's tears have a 15% chance of causing a fear effect, Feared enemies will run away from Isaac temporarily, The chance to fear enemies is affected by your luck stat and at +85 Luck it will activate every time, * dungeon room, blood challenge room, arena pool, item room, treasure room, item room pool, Contents 1 Boss Unlockables 2 Ending Unlockables Press question mark to learn the rest of the keyboard shortcuts. Type: Passive. Related: How to unlock Downpour in Binding of Isaac Repentance. 2. Basement 1, Cathedral, Sheol etc. One of the following messages may show: "Some doors require a blessing. This item is also extra strong in Ascension runs and Greed Mode runs. Pills with effects that can't necessarily 'double' are stronger, i.e. THEGHOST. Like, almost all of the unlocks add something worthwhile or at least situational, as opposed to unlocks like isaac's tears or blood rights or marrow or the 5 billion coop babies. No longer reduces your devil/angel room chances when used, * item room, treasure room, item room pool, the lost item pool, bomb, tnt, clock, red, When used, causes all enemies in the current room to run away from Isaac in fear for 5 seconds. Can only happen once per room, Visually this is almost identical to the Guardian Angel item, but without a face, UNLOCK: Unlock this item by beating Blue Womb (Hush) with The Lost, A white orbiting fly which deals 3 contact damage per tick to enemies, This familiar orbits Isaac at a middle length distance somewhere between Distant Admiration and Forever Alone, Item Pool: Item Room, Greed Mode Item Room, Key Beggar. REPENTANCE - +0.2 Speed Up (Used to be -0.1 Speed before Repentance). UNLOCK: Unlock this trinket by defeating Greedier Mode with ??? In Afterbirth+, taking 3 of this pill gives the Adult transformation, Pretty Fly - Gives Isaac +1 fly orbital, which blocks enemy projectiles and damages fly-type enemies on touch, Range Down - Reduces your range stat by -2, Range Up - Increases your range stat by +2.5, R U a wizard? Use the key to stab the door open and you'll head down to Corpse. Great list! pedestal items, Picking up all dropped items leaves you with the same health and consumables you had before, This allows you to manipulate your consumables in lots of different ways, for example by rerolling them with the D6/D20, re-arrange your Bone heart containers and more, If you have the Tarot Cloth item, this card will also drop all your passive items on the floor as pedestals, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Lost, Gives you a blue aura that repels enemy projectiles, causing them to slowly curve away from Isaac and avoid hitting him, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Judas, Causes Mom's Foot to keep stomping down randomly for 60 seconds where Isaac is standing, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Lilith, Gives 2 HP Up and +1.5 Tears Up for 60 seconds, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Eve, Teleports you to an extra boss room, that drops a Boss room item as normal. UNLOCK: Unlock this item by defeating challenge #36 (Scat Man), When used, places a sword directly above Isaac's head and while active, will spawn an extra item for every item pedestal spawned, After getting hit once with the item activated, at any time without warning, the sword may fall, instantly killing Isaac regardless of his health, After being hit the sword has a 1/10000 chance every 4 frames to fall. Repentance introduces a whole new mechanic of Red Rooms - extra rooms attached to the current floor. Unlock Condition: Defeat The Beast as Tainted Lilith. the lost item pool, gold, orange, yellow, cross, pope, hat, A familiar the follows Isaac and fires random tears, Rainbow Baby's tears can choose from any of the other familiars, such as homing, spectral, tar shots etc, * item room, treasure room, item room pool, purple, Upon use, opens all closed doors in the current room, including the ones which require a key to enter and secret room doors, Can be used to open the golden door that appears in the Dark Room or the Chest, Cannot be used to escape the Mom's Foot boss, open angel/devil rooms, or open the door to the Blue Womb floor, UNLOCK: Unlock this item by collecting both Key Pieces #1 & #2 for the first time, * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool, Using active items gives a damage up that scales with the charge time, ??? purple, pink, circle, guppys collar, All of Isaac's tears now have a shield, allowing them to block an enemy projectile, If a tear blocks something, both Isaac's and the enemies tears are destroyed, * secret room pool, item room, treasure room, item room pool, white, lump, oval, When Isaac takes damage, he will start to leave a trail of blood creep behind him as he walks for the current room. It gives you 2 seconds to pick it up again to re-heal, before it disappears, UNLOCK: Unlock this item by defeating Delirium as Tainted Magdalene, Whenever you deal damage to an enemy, has a chance to give the effect of one of Tainted ??? from Fireplaces, Gives you a familiar which is a smaller version of the Plum boss, which sprays tears and propels itself around the room, Deals 2 contact damage per tick to enemies, and the tears deal 3 damage each, Deals contact damage to any enemies it runs into, UNLOCK: Unlock this item by beating Baby Plum 10 times, When used, this item calls a friendly version of the Plum boss to fight for you for 10 seconds, It will jump to the nearest enemy, slam on the ground and fire tears around it, then propel itself around the room, dealing contact damage to any enemies it touches before disappearing, It's possible to get a guaranteed spawn of this item by encountering the Baby Plum boss and not damaging her. 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